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The resulting holoenzyme dimer comprising the two subunits is catalytically more efficient and less subject to inhibition by GSH than GCLC alone

Abstract Background: Although oxidative stress is known to contribute to cancer, and endogenous and exogenous antioxidants are thought to prevent tumorigenesis by suppressing oxidative stress-induced DNA damage, antioxidants have also been reported to show negative effects on tumor formation, necessitating characterization of the causal associations between antioxidants and cancer risk

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[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Blankestijn J.M., Baalbaki N., Beijers R., Cornelissen M.E.B., Wiersinga W.J., Abdel-Aziz M.I., Maitland-van der Zee A.H., Consortium P.O

This has a much greater impact on melasma clearance compared to antioxidant supplementation

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