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one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide the invention encompasses contacting one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy

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Electron transport through the series of electron carriers in the inner mitochondrial membrane is tightly coupled to phosphorylation

Endurance training also elicits mitochondrial adaptations that enhance fatty acid oxidation capacity [72]

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