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Combination of low grade mucosal inflammation with visceral hypersensitivity and impaired bowel motility could be the underlying etiology for IBS pathogenesis

Based on the above findings, we hypothesized that M1 macrophage-derived exosomal miRNA contributes to the anti-cancer effect of M1 macrophages on melanoma cancer cell lines, which is distinguished from the functions of M2 macrophages

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1C, D), supporting prior data showing that activation of this pathway results in resistance to CDK4/6 inhibitors 18,19,22,23,24

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2.8 Molecular docking The 3D structure for GHK-Cu was retrieved from PubChem and converted into mol2 format with Open Babel 3.1.1