acetaminophen toxicity glutathione / Poisoning Too much paracetamol = dangerous

Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect acetaminophen toxicity glutathione step 1 in Children: Diagnosis, Clinical Assessment, and Treatment of Acute Overingestion Pathways for acetaminophen metabolism. Acetaminophen Acetaminophen toxicity EMCrit Project What is the antidote of choice for acetaminophen poisoning? N acetylcysteine (NAC) Glutathione Answer in the story Acetaminophen hepatotoxicity: An update Current Gastroenterology Reports Springer Nature Link

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