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M., Paradinas, F

doi: 10.1016/j.surg.2015.07.003

A proposed mechanism links intestinal dysbiosis, obesity, and metainflammation, and identifies the intestinal barrier as the trigger of an inflammasomemicrobiota axis [144]

Further increases can be made in 2.5 mg increments (to 7.5, 10, 12.5, and 15 mg) at intervals of at least 4 weeks based on clinical response and tolerability