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Similarly, activating the Nrf2/HO-1 axis to enhance cellular antioxidant gene expression can hamper ferroptosis, although the potentially excessive iron release from high HO-1 expression must be considered (174)

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The Fe(II) site was, however, well-defined by the data, revealing an octahedral Fe(II) coordination site, with three protein-derived ligands, H56, H119, and D145, arranged as a facial triad on one side of the Fe(II), and three open coordination sites modeled with high occupancy water molecules (Fig

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