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SARS-CoV-2 can activate mitochondrial ROS production, especially in older individuals having ROS overproduction, enhancing oxidative stress and promoting endothelial dysfunction, cardiovascular disease and lung injury

Nato Sci

Disturbance of the lens cell membrane permeability during the development of cataract, and reduced ability of active transport of substances against the concentration gradient lead to changes in concentration of intracellular compounds and metabolic changes within the cells

Nat Rev Immunol 18:134147

On the other hand, higher levels of glutathione reduced the oxidative stress in cancer cells

The observed increase in mitochondrial malate and cytosolic 2-oxoglutarate through elevated SLC25A11 expression aligns with the systemic energetic dysregulation and oxidative stress reported in plasma metabolomic studies in ME/CFS patients