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Fluoride being beneficial at minimal concentrations was used for dental caries prevention, but excessive exposure of fluoride has been associated with numerous health disorders including skeletal and dental fluorosis, weakening of bones making them more prone to fractures, impaired intelligence, stunted growth, reduced birth and fertility rates, and disruption of thyroid function

At a glance Drug / isotretinoin (Accutane), oral retinoid for severe nodular acne Supplement / omega-3 fatty acids (EPA + DHA), typically from fish oil or algae oil Primary interaction type / pharmacodynamic (lipid and platelet pathways), not pharmacokinetic Triglyceride effect / isotretinoin raises triglycerides in up to 44% of patients

Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term studies in animals to evaluate carcinogenic potential have not been done

in a Korean population 38 and by Leem et al

(3) Zhang C, Xie Y, Chen H, Lv L, Yao J, Zhang M, Xia K, Feng X, Li Y, Liang X, Sun X, Deng C, Liu G

Growth hormone promotes lipolysis and lean tissue preservation