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However, the active development of the microfluidic BBB systems in recent years demonstrates the potential of these models for a variety of research tasks ( Cell aggregate models or spheroid models consist of endothelial cells, astrocytes, and pericytes, which are able to self-organize into spherical structures with astrocyte core, surrounded by pericytes and covered with endothelial cells (Urich et al., 2013)

doi: 10.1016/j.anireprosci.2016.01.007 121

J Biomed Sci 24:113 Choi YJ, Park SJ, Park YS, Park HS, Yang KM, Heo K (2018) EpCAM peptide-primed dendritic cell vaccination confers significant anti-tumor immunity in hepatocellular carcinoma cells

Biomaterials 142:112

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People who hope to get the benefits of raspberry ketones without the risk should consider eating more raspberries