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86 DRAM1 participates in the regulation of autophagy and apoptosis in intestinal epithelial cells by positively regulating JNK, and knockdown of DRAM1 can lead to a decrease in the phosphorylation levels of c-Jun and JNK, inhibit the formation of autophagosomes, and alleviate the symptoms of UC

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In this review, we discuss the roles of TDLNs in cancer metastasis, the impact of cancer cell progression and invasion on the LN immune microenvironment and the function of TDLNs in immunotherapy, as well as the opportunities and challenges in targeting LN metastasis for improving patient care

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