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3 Ferroptosis and neurodegenerative diseases Iron is an essential trace element for maintaining brain function, playing vital roles in neuronal development, neurotransmitter synthesis, mitochondrial energy metabolism, myelin formation, and synaptic plasticity (Table 1), suggesting that therapeutic targeting of ferroptosis may offer a promising strategy for the prevention and treatment of NDDs

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indeed, if some studies showed that the hormone is able to significantly downregulate autophagy in different disease models 63,64,65 , other reports failed to confirm those findings, providing evidence for an enhancement of the autophagic process upon melatonin treatment 66,67,68

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