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In addition, 2-hydroxyglutarate (2-HG) produced by IDH1/2 mutation [32], as well as the accumulation of succinate and fumarate caused by mutations in fumarate hydratase (FH) [78] and succinate dehydrogenase (SDH), can not only promote the Warburg effect by inhibiting the degradation of HIF [79], but also enhance the methylation level of the whole genome by inhibiting TET enzymes [80]

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