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The balance of the different CRP isoforms, monomeric (mCRP) or native pentameric (nCRP) within the plaque determines the preponderance of a proinflammatory or anti-inflammatory effect, respectively (165)

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First, the PCA showed that the plasma samples from different experimental classes were not grouped separately (Data shown in Supplementary Figure S2)

References Wax B, Kerksick CM, Jagim AR, Mayo JJ, Lyons BC, Kreider RB

Unlike previous approaches that typically focused on a single therapeu- tic function, this system is specifically engineered to simulta- neously target oxidative stress, infection, and impaired tissue regeneration in diabetic wounds

doi: 10.3389/fendo.2022.962968 263 Di MaioGAlessioNPelusoGPerrottaSMondaMDi BernardoG