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It develops when fibrous connective tissue (septae) hardens with age and pulls the skin downward while underlying fat pushes upward, creating a dimpled appearance

The management of ASD often involves a cross-disciplinary approach combining educational interventions, behavioral, speech-language, and occupational/physical therapies, alongside medical treatments [2]

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This angiogenic switch activates the formation of new blood vessels in the tumor in order to ensure survival and growth by carrying oxygen and nutrients into the tumor