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The bridge from genes changed to cell function changed is still half-built, and most of the published work leans on dermal fibroblasts, with far less on the cardiac, lung, or joint varieties, which makes generalizing across tissue types shakier than it sounds

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Alterations in glutathione, nitric oxide and 3-nitrotyrosine levels following exercise and/or hyperbaric oxygen treatment in mice with diet-induced diabetes

& Ross, P

Thus, the development of additional therapeutic options is urgent, as is the establishment of combinatorial regimens to improve efficacy and reduce the potential for the emergence of drug-resistant variants

PloS One (2016) 11(3):e0151848