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We demonstrated that exposure of microglia to the chosen cART cocktail induced generation of reactive oxygen species, subsequently leading to lysosomal dysfunction and dysregulated autophagy, ultimately resulting in the activation of microglia

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One of the investigations reported that NPs were loaded with nuclear factor kappa B (NF-B) inhibitors, a key regulator of inflammation, which could suppress the microglial activation and decrease the production of pro-inflammatory cytokines