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A central hydrophobic domain is responsible for the membrane association of the core, whereas the high pI of an N-terminal region mediates its interaction with RNA

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Inadequate oxygen utilization in tissue caused by poisoning of cellular oxidation enzymes or a diminished cellular metabolic capacity for using oxygen caused by toxicity (e.g., cyanide poisoning), vitamin B 1 deficiency (e.g., beriberi), or other factors

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It is studied in metabolic research models for its effects on adipocyte energy expenditure and lipid metabolism

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doi: 10.1523/jneurosci.2108-10.2010 146 MitchellP.LiewG.GopinathB.WongT

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