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In particular, some studies report the ratio of free GSH to GSSG [19, 22,23,24,25,26], whereas others quantify and report total GSH (i.e., free GSH + 2xGSSG) [12, 19, 24, 26,27,28,29,30]

It can also be remethylated using glycine betaine (NNN-trimethyl glycine) to methionine via the enzyme Betaine-homocysteine methyltransferase (E.C.2.1.1.5, BHMT)

doi:10.1021/cr500131f

ThermoFisher, Waltham, MA, USA) and affixed to microscope slides

The metabolite of MPTP, MPP + , induces mitochondrial dysfunction, increases oxidative stress, and leads to neuronal death, exhibiting PD-like pathological characteristics 21