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Heroin, an opioid, primarily modulates G protein-coupled receptor activity and affects neuronal excitability and reward pathways

5-reductase-2 subjects both adults and children also have abnormal ratios of 5- to 5-reduced glucocorticoid and other steroid metabolites, indicating that this condition is a generalized defect in hepatic steroid 5-metabolism, clearly distinguishing them from androgen-insensitive subjects who may also have abnormal T/DHT ratios (18)

13.0 1.3 years, p = 0.015)

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