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Description

Racchi M, Mazzucchelli M, Pascale A, Sironi M, Govoni S

Immunity 23 , 419429 (2005)

Trace elements in human nutrition (II) - an update

Thus, the PPPgenerated NADPH rescues xCT-overexpressing cancer cells (xCT high cancer cells) from ferroptosis, demonstrating that xCT high cancer cells become highly dependent on the glucose-PPP pathway (i.e., NADPH addiction) to inhibit ferroptosis [Figure 1A]