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These conditions are particularly noticeable in the tumor microenvironment (TME), where vasculature is limited 2

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ANGPTL4 initiates the activation of the Janus kinase-signal transducer and activator of transcription 3 (JAK/STAT3), mediated upregulation of inducible nitric oxide synthase (iNOS) expression in wound epithelium, and promotes angiogenesis