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Jain M, Tsai LF, Robertson D, Hirshberg B, Hockings P, Johansson L, et al

M.MichieliP

There are two related reasons for our proposal

Residue specific assignments were obtained from 2D total correlated spectroscopy (TOCSY) and correlation spectroscopy (COSY) experiments, while 2D nuclear Overhauser effect spectroscopy (NOESY) permitted sequence specific assignments

Amylin acts on (1) appetitive/energy-regulating neurons in the hypothalamus impacting food intake, (2) dopaminergic neurons in the ventral tegmental area impacting reward and motivation, and (3) chemoreceptive neurons in the area postrema/nucleus tractus solitarius [60]