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1197 While the primary effects of rapamycin are attributed to alterations in T cells, it also inhibits BAFF-mediated mTORC1 signaling in B cells, thereby limiting their proliferation and survival

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Isotopically labeled metabolic substrates were used to monitor generation of 3 H 2 O from glycolysis or beta oxidation and 14 CO 2 from the pentose phosphate pathway, glutamine utilization, or TCA cycle