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10.1016/j.yjmcc.2014.09.009 78

Aging is another factor, as older adults may have a reduced ability to absorb nutrients like vitamin B12 and may produce less CoQ10 naturally

Aristofania Simatou

A 138A, 133140

Among them, the GCN2-ATF4 pathway is activated under amino acid starvation: GCN2 senses uncharged tRNAs and activates the transcription factor ATF4, which in turn upregulates the expression of amino acid transporters such as SLC3A2 and SLC7A5 [56,57]