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The Pro-Gly-Pro tail in Selank slows that degradation dramatically and also improves blood-brain-barrier permeability, which is why the compound is delivered intranasally rather than orally

In addition, NaHS treatment increased CBS and CSE activity, normalized levels of H 2 S and polysulfides in brain homogenates, and reduced the Hcy-induced production of pro-inflammatory mediators (i.e., IL-6 and TNF-) and the expression of the inflammatory enzyme inducible nitric oxide synthase (iNOS)

[DOI] [PMC free article] [PubMed] [Google Scholar] 122.Aghakhanyan G., Galgani A., Vergallo A., et al

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14,15 There is no known ethnic predisposition to DJS, although Sephardic Jews have been noted to have a higher frequency of disease burden

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