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however, they are much less efficient than the dismutation reaction of O 2 catalyzed by SOD (the rate constant is ~10 9 M 1 s 1 )

Hypoxia inhibits PHD, which stabilizes HIF- and promotes its migration to the nucleus where it dimers with the subunit and binds to the promoters or enhancers through the hypoxia response elements (HRE) to initiate gene transcription (19, 20)

Early detection helps prevent long-term symptoms

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Viola JR, Lemnitzer P, Jansen Y, Csaba G, Winter C, Neideck C, Silvestre-Roig C, Dittmar G, Doring Y, Drechsler M, Weber C, Zimmer R, Cenac N, Soehnlein O

Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin