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Notably, pronounced cell death was observed in FADS-knockdown HCC cells, with cell membrane rupture (Fig

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3.3.1 Matrix metalloproteinases and their inhibitors MMPs are a class of enzymes that degrade extracellular matrix proteins and play a crucial role in tissue remodeling and the renewal of the extracellular matrix ( Tissue inhibitor of metalloproteinases (TIMP-1) serves as an endogenous inhibitor of MMPs preventing their excessive degradation of the extracellular matrix through binding interactions ( 3.3.2 Fibronectin Fibronectin, a multifunctional protein found within the extracellular matrix, is crucial for cell adhesion, migration, and tissue repair.The findings showed a notable rise in fibronectin concentrations in cervicovaginal secretions from patients who were undergoing premature rupture of the membranes

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