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Age effects and folate status, a modifier of vitamin B 12 metabolism, are also considered (Fedosov et al., 12 status, cB 12 , is defined as: cB 12 = log10((holo-TC.B 12 )/(MMA.tHcy))(age factor) (Fedosov et al., 12 status provides five distinct ranges of diagnostic value, which are summarized in Table 1

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524 In the advanced stages of atherosclerotic disease, macrophages destroy the collagen of the fibrous cap and induce smooth muscle cell death by secreting multiple types of inflammatory factors and matrix metalloproteinases (MMPs), thus exacerbating plaque instability

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10.2147/DDDT.S43964 92 Jimnez-ArellanesA.Luna-HerreraJ.Cornejo-GarridoJ.Lpez-GarcaS.Castro-MussotM