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[Abstract]2023 Jun:176:113785

The result: GHK-Cu changes the expression of 4,192 human genes Tendency: resets expression toward a younger phenotype Genes related to ageing are regulated downward Genes related to regeneration are regulated upward Including DNA repair genes , this may contribute to an anti-mutagenic effect This is an unprecedentedly broad transcriptomic effect of a single molecule

Zisapel, N

Control of cell cycle and immortality YY1 Studies have suggested that ying yang 1 (YY1) potentiates small ubiquitin like modifiers (SUMO)-specific protease 1 (SENP1) expression which was shown to repress SUMO modification of METTL3