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Huang L, Cai Y, Luo Y, Xiong D, Hou Z, Lv J, et al

[15] Finally, the cytosolic oxaloacetate is converted to phosphoenolpyruvate by PEP carboxykinase

Vaccine 23 , 21322135 (2005)

Retinal manifestations Although primary retinal ganglion cell (RGC) loss involving the inner retina and optic atrophy are classical manifestations of mitochondrial disease (discussed in Optic Neuropathy below), outer retinal involvement is also observed as part of the phenotype of several syndromic central nervous system diseases caused by mtDNA mutations

10.1155/2022/4591134 141 ZhongQ.SunW.QinY.XuH

The rapid shifts in osmolarity associated with HD also increase the risk of further elevations in intracranial pressure, especially in neonates