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Moreover, AS-IV can interfere with the influence of TGF-1 stimulation on the incorporation of [3H]proline in HSCs, as demonstrated by the decreased incorporation amount and inhibition of TGF-1-induced proliferation and collagen synthesis in HSCs, thereby alleviating PS-induced immune hepatic fibrosis (Fig

Figure 3 3.3 Socioeconomic and health system impact PD imposes a significant socioeconomic burden, including direct healthcare costs (e.g., medications, hospitalizations, and surgery) and indirect costs (e.g., lost income, caregiver absenteeism, and reduced productivity)

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