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Fernandez-Checa, J

Certainly, early life stressful events such as maternal separation in the rodent, or child abuse/loss of a parent in humans can cause disruption of the HPA axis in this way ( In addition to, or perhaps as a result of, disrupting the HPA axis, the parental influence at this time is also crucial for establishing feeding patterns long-term

A study revealed that estradiol supplementation could suppress high glucose-induced apoptosis in trophoblasts, mitigate oxidative stress, and reduce placental necrosis in mouse models of GDM [30]