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The choice of procedure is guided by the joint involved, severity of structural damage, patient age, activity level, and comorbidities (Table 3) (Katz et al., 2010

For example, the histone variant H2A.J accumulates in keratinocytes after IR and tunes senescence-associated secretory phenotype (SASP), which participates in the development of radiation dermatitis (RD) together with the epigenetic regulation of TGF--driven myofibroblast program [15]

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Conversely, a poor diet and obesity are associated with GM alterations, cognitive dysfunction, and an increased risk for dementia [reviewed in (511)]

doi: 10.1111/odi.12048 55