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JAMA 306(14):15491556

The aim of this paper is to review the role of ROS in normal physiological functions, ROS-mediated cellular signaling, and the role of oxidative stress in various chronic diseases and aging

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SEC61b and KDEL, which indicate rough ER and ER sheet, respetively 40 , predominantly localize to the cell body

This approach moves away from the traditional one-size-fits-all model and instead focuses on personalized, biomarker-guided targeted therapies and best practices tailored to an individual's unique biological profile (263)

Summary and prospect With the discovery that FSP1 can regulate ferroptosis independent of GPX4, researchers have become more enthusiastic about finding GPX4-independent ferroptosis pathways