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A higher production of reactive oxygen metabolites, such as the superoxide anion, affects catalase activity 45 , and an increase in production of hydroxyl ions reduces catalase activity 46

When reactive oxygen species threaten your cells, glutathione steps in and neutralizes them, helping to manage oxidative stress

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In most cell types, however, hIDO1 is not only expressed constitutively under normal physiological conditions, but the enzyme is strongly induced in response to inflammation and infection stimuli, with IFN- being the main inducer [132,133], making IFN--mediated hIDO1 induction and local L-Trp depletion an important factor able to inhibit pathogen growth [134]