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K.JangH

In addition, xanthurenic acid(XA), a downstream metabolite of 3-HK, can inhibit tetrahydrobiopterin(BH 4 ) synthesis, interfere with neurotransmitter balance, and exhibit a unique inhibitory effect on tumor cell motility in GBM (Staats Pires et al., 2020)

PMID: 27334313

doi: 10.1016/S0002-9394(00)00359-7 113 ChandranGSirajudeenKNYusoffNSSwamyMSamarendraMS

Although not previously considered, riboflavin (vitamin B2) is also required, along with pyridoxal phosphate, for the activation of KMO ( As in RA, the AHRs seem to play a significant role in the regulation of bone turnover and fragility