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10.1182/blood.v126.23.3059.3059 215 WangD.MengG.ZhengM.ZhangY.ChenA.WuJ.et al (2016)

The receptor is translocated to the nucleus upon androgen binding and ultimately results in the transcriptional regulation of a number of genes via androgen responsive elements

In the first clinical study, a multicentre, randomised, double-blind, placebo-controlled, parallel-group study by De Grandis et al

The androgen-positive effects on muscle growth might be also elicited through the Notch signaling

While it does not cure PEM, it may help raise the threshold at which a crash is triggered, providing patients with a slightly larger, more forgiving energy envelope