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Results showed measurable, dose-dependent uptake of 5-MTHF by dermal fibroblasts, which remained stable for up to 48 hours, suggesting prolonged cellular repair

thus, it is considered promising to prevent endothelial dysfunction, proliferation of smooth muscle cells, and inflammation

International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use

To meet the demands of rapid proliferation, tumor cells undergo significant metabolic reprogramming, including enhanced reliance on cystine uptake and redox balance (59)

doi: 10.1002/prca.200600770

The derivatives with corresponding R -configuration were postulated to be essentially inactive in all cases