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Collectively, these findings demonstrate that mitochondrial D -2HG driven by HOT affects wild-type IDH2 activity (52)

In the trial, 300 subjects were enrolled and presented with the Fragment 176-191 peptide for 12 weeks

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10.1016/j.biopha.2020.110058 Summary Keywords anti-fibrotic, natural products, idiopathic pulmonary fibrosis, therapeutic target, mechanisms of action Citation Ma M, Chu Z, Quan H, Li H, Zhou Y, Han Y, Li K, Pan W, Wang D-Y, Yan Y, Shu Z and Qiao Y (2025) Natural products for anti-fibrotic therapy in idiopathic pulmonary fibrosis: marine and terrestrial insights

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PERSPECTIVE The liver is essential for survival as no other organ can compensate for its multiplicity of functions, for example, its well-known functions in metabolism, detoxication, and decomposition of toxic substances