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TSH secretion, and its sensitivity to TRH stimulation, is affected by renal failure, starvation, sleep deprivation, depression, and hormones, including cortisol, growth hormone, and sex steroids (89, 128)

Nat Commun 8(1):1287 Nordin A, Larsson E, Thornell L-E, Holmberg M (2011) Tissue-specific splicing of ISCU results in skeletal muscle phenotype in myopathy with lactic acidosis, while complete loss of ISCU results in early embryonic death in mice

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Changes in hepatic factor levels induced by diet also have implications for CNS function

Below, two important phenomena are discussed, namely ferroptosis as a weapon of immune cells against tumors, as well as the opposing phenomenon, i.e., ferroptosis as a mechanism suppressing immune defense

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