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Filiano AJ, Xu Y, Tustison NJ, Marsh RL, Baker W, Smirnov I et al (2016) Unexpected role of interferon- in regulating neuronal connectivity and social behaviour

In certain models, it appears to influence fibroblast activity, collagen production, and glycosaminoglycan synthesis

This idea posits that excessive dopaminergic activity in the course of mania precipitates dopamine receptor down-regulation, which subsequently triggers a transition into a depressed state (245)

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In the majority of cases, they are caused by everyday factors rather than any underlying disease, and knowing these can help you address them more effectively

5 Importantly, the decision to discontinue GH in very poor responders could also be made sooner