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Vitamins tend to work in a system of use and replenish. Vitamin B12 travels through the bloodstream and is eventually expelled through urine

"What Is Pernicious Anemia?"

[10] Enzyme-inducing anticonvulsants such as phenytoin, carbamazepine, and phenobarbital, as well as rifampicin, accelerate hepatic catabolism of vitamin D, shortening its half-life and potentially necessitating more frequent or higher intramuscular doses to sustain target 25-hydroxyvitamin D levels

This falls well within the allowable excursion parameters that pharmaceutical stability testing accounts for

Age-related decline: As people age, stomach acid levels drop, making it harder to absorb B12

Phentermine: Pharmacological Monograph (PIM 415)