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As NAG serves as an essential allosteric activator of carbamoyl phosphate synthetase I, this inhibition impairs ammonia clearance, culminating in hyperammonemia (Lee and Kim 2022)

Individuals with severe MMA are at increased long-term risk for neurologic injury (e.g., metabolic stroke, seizure), poor feeding, and failure to thrive [6]

The elevated levels of TMAO in the blood of patients with ESRD have profound implications for their health status and comorbidities

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