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Aging Liu and coworkers have systematically evaluated the effect of aging in rodents on GSH homeostasis in different tissues and found that GSH level falls in all tissues with age, due to a corresponding fall in GCL and GS gene expression (no change in GGT, GSH reductase expression, cysteine availability or GSSG as an indicator of oxidative stress) (Wang et al., 2003

Approximately 40-50% of ER+ breast cancers harbor PI3KCA mutations, which are associated with increased GSH synthesis and resistance to oxidative stress, ultimately reducing the sensitivity of ER+ breast cancer to ferroptosis [21]

For most individuals, B12 injections are safe and well-tolerated

Malkki H

Thus, there is perhaps no contradiction, and CMA is proferroptotic