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Glycine is also vital for producing cysteine and glycine-rich protein 2 (CSRP2) by glioma cells, which contributes to tumor progression by promoting malignant proliferation, metastasis, stemness, and chemoresistance through activation of the Notch signaling cascade [79]

Cancer Hcy competes with SAMe, affecting DNA methylation and harming brain function, which can lead to mental health and nervous system disorders

In many cases, the preferred treatment modality is generally non-surgical, with surgery being considered the alternative of last option ( As we all know, bFGF is a mitogenic factor isolated and purified from bovine brain, which has an important role in wound healing and cell proliferation (including vascular endothelial cells, fibroblasts, nerve cells, and tendon cells), and osteogenesis (Zhou et al., 2021)

Hu W, Ru Z, Zhou Y, et al

Diagnostic and Statistical Manual of Mental Disorders, 4th edn, text revision

Pai CC, Durley SC, Cheng WC