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TMAO t 1/2 was estimated by fitting linear regression to log-transformed concentrations over the final three time points of each curve, corresponding to the terminal elimination phase, following standard log-linear pharmacokinetic modeling methods

First-generation sulfonylureas are associated with a greater risk of adverse effects, including hypoglycemia, weight gain, and fluid retention, making second-generation drugs the recommended choice in clinical practice (126, 127)

5 Combined ferroptosis-cuproptosis strategy for OSCC The extensive crosstalk between ferroptosis and cuproptosis across metabolic and signaling networks furnishes a strong mechanistic rationale for their simultaneous induction

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Calvello R, Aresta A, Trapani A, Zambonin C, Cianciulli A, Salvatore R