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For instance, efficacy and BBB permeabilization properties of ADCs, the influence of drug-to-antibody ratio (DAR) on payload concentration and their diffusion with target tissue/cell selectivity, linker design, and potential of payload smartly bypassing multidrug efflux transporters (e.g

1 Introduction Epilepsy is a common chronic neurological disorder, with approximately 50 million people living with epilepsy worldwide and 5 million new cases each year

Screening efforts to explore the pharmacopeia for antimicrobial compounds also identified auranofin and ebselen for antimicrobial properties that appear to also target TrxR (Figure 2)

He is willing to contribute to the publication of this manuscript and has provided important insights into the coexistence of hyperthyroidism-related hepatic injury and drug-induced liver injury

In thyroid cancer (TC), this manifests as a classic DNA methylation paradox: global hypomethylation coexists with focal hypermethylation in the promoter regions of specific tumor suppressor genes [12]