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20 Primarily, NADPH provides reducing equivalents for fatty acid synthase (FASN), the main rate-limiting enzyme, to synthesize fatty acids with acetyl-CoA serving as a primer and malonyl-CoA as a two-carbon donor, 21,22 and provides the needed electrons for ironsulfur (Fe/S) protein assembly that participate in non-essential amino acid biosynthesis and lipoic acid synthesis, tRNA modification, DNA replication and repair, and telomere maintenance

These functions make NAC supplementation a viable therapeutic option for various health issues

doi: 10.1016/j.cell.2021.12.039 303

Acknowledgements This work was supported by the National Science Foundation of China (21405071, 21535002, 21227008), Special Funds for the Construction of Taishan Scholars (grand No

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Materials and methods: This study is based on the analysis of secondary malariometric data available with the routine malaria surveillance system of Boudh, a historically Pf malaria endemic district