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The cell needs PARP1 activation to protect genome integrity, yet too much activation can drain NAD+ pools

[DOI] [PubMed] [Google Scholar] 329.Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB

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How B12 Works and Why Seniors Are Vulnerable Vitamin B12 (cobalamin) is a water-soluble nutrient essential for red blood cell formation, DNA synthesis, and maintaining the myelin sheath that insulates and protects nerves

[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy

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