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doi: 10.2353/ajpath.2009.080804 31

98 COL1A1 (induction of EMT activation) and VDAC2 (regulation of ferroptosis sensitivity) are direct target genes of miR-577

One study confirmed that paradox induces apoptosis in the HT-1080 cell line by inhibiting caspase and disrupting the mitochondrial membrane, releasing Cytc